Viburnum prunifolium, commonly known as black haw, is a deciduous shrub native to eastern North America. It has been used in ethnomedicine for its spasmolytic, sedative, and anti-asthmatic properties. Black haw, mainly its bark, has been widely used by Native Americans primarily to treat gynecological conditions. Additionally, the Cherokee have used black haw as an infusion or a tonic to prevent recurrent spasms, or for fever, smallpox, and ague. They also used an infusion of the bark as a wash for sore tongues. The Lenape combined the root bark with leaves of other plants and used it to strengthen female generative organs.

Black haw was reported to contain iridoids, which have shown anti-oxidant, anti-inflammatory, and anti-microbial activities. Studies for its bioactivity and health benefits are lacking, but other species have been studied. For instance, V. opulus and V. lantana were reported to have strong anti-oxidant activity analyzed by DPPH assay.