The Art of NATURE, The Art of SCIENCE
Common names | Mayapple, American mandrake
Scientific name | Podophyllum peltatum
Used part | Root
Known active compounds | podophyllotoxin, picropodophyllin
Potential benefits in cosmetics | anti-fungal
Product name | Mayapple Root-ANB
Plant Story
Podophyllum peltatum, mayapple or American mandrake, is native to eastern North America belonging to the barberry family (Berberidaceae). It is also known as umbrella plant or wild lemon, having one or two large umbrella-like leaves and a single, yellowish, lemon-like fruit. For centuries, mayapple has been used by Native Americans for medicinal purposes. For instance, its powdered roots were used to treat warts and tumorous growth on the skin. In addition, Native American tribes such as the Cherokee used mayapple as an anti-rheumatic, cathartic, dermatological aid, ear medicine, insecticide, and laxative.
Podophyllotoxin is a major bioactive constituent of podophyllin resin, a mayapple resin extract, and is the most abundant lignan isolated from podophyllin, followed by others like 4-demethyl-podophyllotoxin, β-peltatin, and α-peltatin. Podophyllin was included in the US Pharmacopeia in 1820, primarily attributed to the biological activities of podophyllotoxin. Podophyllotoxin and its ester derivatives have shown anti-fungal activity.